baiwanwanrencaigongchengguodujirenxuan

张 健

2017-11-18 20:00   来源:澳洲幸运10走势    作者:    点击:

zhangjiangxuezhe: zhangjian chuanshou

  zhangjian, “zhangjiangxuezhejiajiangdasuan”tepinchuanshou,bodao ,guodujingcaiqingniankexuejijinhuodezhe,xinshijibaiwanwanrencaigongchengguodujirenxuan。1963niandanshengyuhunanzhangshaxian,1987nianfumeiliuxue, 1992nianzaimeiguomaiamidaxueyixueyuanshengguitianxuejifenzishengwuxuexihuoboshixuewei,1993-1994nianzaimeiguomaiamidaxueyixueyuanyixuexichuzhiboshihouyantaorenwu,erhouyixiangzaimeiguoyeludaxuefenzi、xibaojifayushengwuxuexichuzhiboshihouyantaorenwu。2000nianfanguozhaopinweiaozhouxingyun10zoushi tepinchuanshou,tongnian8yuebeijiaodaobuhezhunwei“zhangjiangxuezhejiajiangdasuan”tepinchuanshou,binghuodeguodujingcaiqingniankexuejijinketi。2001nianhuoyouhunanshengshengweigouzaobu、renshitingheshengkexiejiehebanfade“hunanshengqingniankejijiang”。zhangjianboshiyixiangzaixingmingkexuedeqianyanfanchouchuzhiyantaorenwu,chugeshiliuxuemeiguode13nianzhong,shitazaigudaifenzishengwuxuefanchoujubeileshenzhideshijigenben,bawolejiyinkelong、jiyinshufa、jiyinqiaochuhezhuanjiyinzhiwudenggeleijinbuqianbeijishu,yehuodelererenzhushidechengjiu。tadeshouyaogongxiaoshi: (1)chucicongniudegouzaoherendehepg2xibaopingfenbiekelonglednajuhemeicuihuayajijixiaoyaji,bingyongjijiaojiruanjianduidnajiluanbaizhixulietingzhilechanfa。(2)jingyoujinchengzhuanluyinziap-2ajiyindeqiaochujiqiaochuap-2ajiyinhoulaoshudebiaoxingdechanfa,faminggaijiyinshiburuzhiwululianbufayudegenjidiaokongyinzi,bingweiyanqiujingzhuangtixiaopaodechuqixingzhuangchanshengsuobixu。cichengguobanfazaitianxiawenmingxueshuzazhi《nature》shang,beiguojitongyeyuanyongda220ci。(3)yongzhuanjiyinxiaoshumozichakandaoap-2azairuxianzhongdedapishufanengannaruxiandefayu,bingfamingap-2jiyinjiashu(ap-2a、β、γ)debiciganhuanenggouzairuxianaibianjinchengzhongqishouyaoganhua。(4)famingbingkelonglepdip1jiyinjiashudesangejiyin,bingfaminggaijiyinjiashujubeikangxibaodiaowanghezengjinganqiechushuhouganzangxiufudeganhua。1991nianzhijin,zhangjianzaiwaiyangwenmingxueshuzazhishangbanfalunwen10yupian,junbeiscishoulu,beiguojitongyeyuanyongcishuda500yuci。

  jinchaoyizaiaozhouxingyun10zoushi xingmingkexuexueyuanchenglilejinbuqianbeidejiyinqiaochuyuzhuanjiyinzhiwuyantaoshi,qingqiuhezhangguanleguodujingcaiqingniankexuejijin、guodutianrankexuejijin、jiaodaobuzhongdianketi、hunanshengjiaodaotingzhongdianmingmu、hunanshengtianrankexuejijindengduoxiangketi,bingdaochangleguodu863yanzhongzhuanxianghemianshangmingmu,zhankaijiyinqiaochuyuzhuanjiyinzhiwudeyantao。zhangguanxuexiaoshiwushidai211gongchengzhongdianjianshemingmu—“fayushengwuxueyuluanbaizhihuaxuejiluanbaizhiyaowugongcheng”zimingmu“luanbaizhiyaowugongcheng”dejianshe。jinchaozhidianyoushuoshisheng、boshisheng20yuming。

fushouyaodaibiaozuo:

  1.               Zhang,J.,Donaldson,S.,Serbedzjia,G.,Elsemore,J.,Plehn-Dujowich,D.,McMahon,A.,Flavell, R. A.  and T.Williams (1996) Neural tube, skeletal and body-wall defects in  mice lacking the transcription factor AP-2.Nature,381,238-241.          
  2.               J. Zhang, Y. Sun, Y. Liu, Y. Sun and D.J. Liao(2004) Synergistic effects of androgen and     estrogen on the mouse uterus and mammary gland. Oncology Reports,12(4):709-716          
  3.               Zhang J, Brewer S, Huang J, Williams T.(2003)Overexpression of transcription factor AP-2 alpha suppresses mammary gland growth and morphogenesis. Developmental Biology, 256(1):128-146          
  4.               Zhang J., T. Williams,(2003)Identification and regulation of tissue-specific cis-acting elements associated with the human AP-2 gene. Developmental  Dynamics,228(2): 194-207.          
  5.               Sanjay Anand, Wayne C. H. Wang, Dennis R. Powell, Stacey A. Bolanowski, Jian Zhang, Christina Ledje, Aruna B. Pawashe, Chris T. Amemiya, and Cooduvalli S. Shashikant. Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes, PNAS 2003 100: 15666-15669          
  6.               Zhang J.,Tan, C.-K., McMullen B., Downey, K.M. and A.G. So(1995)Cloning of the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene. Genomics,29(1),179-186.            
  7.               Zhang, J., Chung, D., Tan, C.-K., Downay, K. M., Davie, E. W. and A. G. So (1991) Primary structure of the catalytic calf thymus DNA polymerase δ: sequence similarities with other DNA polymerase. Biochemistry 30, 11742-11750.          
  8.               West-Mays, J. A.,Zhang, J., Nottoli, T., Donaldson, S., Libby, D., Strissel, K.J. and T.Williams(1999)AP-2a transcription factor is required for early morphogenesis of the lens vesicle. Developmental Biology, 206,46-62.          
  9.               Turner, B.C., Zhang, J., Gumbs, A.A., Maher, M.G.,Kaplan, L.,Carter, D., Glazer, P.M.,Hurst, H.C.,Haffty, B.G. and T. Williams(1998)A high incidence of AP-2 gene expression in human breast cancer correlates with the regulation of multiple growth factor pathways. Cancer Research,58,5466-5472.          
  10.               Nottoli, T., Donaldson,S., Zhang, J., Perkins, A. and T. Williams (1998) AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.   Proc.Natl.Acad.Sci.USA, 95,13714-13719.          
  11.               Chung, D., Zhang, J., Tan, C.-K., Davie, E. W., So, A. G. and K. M. Downey (1991) Primary structure of the catalytic subunit of human DNA polymerase δand chromosomal location of the gene. Proc.Natl.Acad.Sci.USA,88, 11197-11201.          
  12.               Tan, C.-K., Zhang, J., Li, Z.-Y., Tarpley, W. G., Downey, K. M. and A. G. So (1991) Functional characterization of  RNA-dependent DNA polymerase and RNase H activitiesof a recombinant reverse transcriptase. Biochemistry ,30, 2651-2655          

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